On This Day, April 21
- 2021: Indonesian Navy submarine KRI Nanggala (402) sinks in the Bali Sea during a military drill, killing all 53 on board.
- 2019: Eight bombs explode at churches, hotels, and other locations in Sri Lanka on Easter Sunday, killing at least 269.
- 2014: The American city of Flint, Michigan switches its water source to the Flint River, beginning the ongoing Flint water crisis which has caused lead poisoning in up to 12,000 people, and at least 12 deaths from Legionnaires' disease, ultimately leading to criminal indictments against 15 people, five of whom have been charged with involuntary manslaughter.
- 2012: Two trains are involved in a head-on collision near Sloterdijk, Amsterdam, in the Netherlands, killing one person and injuring 116 others.
- 2010: The controversial Kharkiv Pact (Russian Ukrainian Naval Base for Gas Treaty) is signed in Kharkiv, Ukraine, by Ukrainian president Viktor Yanukovych and Russian president Dmitry Medvedev; it was unilaterally terminated by Russia on March 31, 2014.